High Throughput Screening of Co-Expressed Gene Pairs with Controlled False Discovery Rate (FDR) and Minimum Acceptable Strength (MAS)

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High Throughput Screening of Co-Expressed Gene Pairs with Controlled False Discovery Rate (FDR) and Minimum Acceptable Strength (MAS)

Many exploratory microarray data analysis tools such as gene clustering and relevance networks rely on detecting pairwise gene co-expression. Traditional screening of pairwise co-expression either controls biological significance or statistical significance, but not both. The former approach does not provide stochastic error control, and the later approach screens many co-expressions with exces...

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1Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand 2Graduate School of Science and Engineering, Yamaguchi University, Yamaguchi 753-8511, Japan 3Department of Veterinary & Biomedical Sciences, College of Agriculture & Biological Sciences, South Dakota State University, Brookings, SD 57006, USA 4Center of Infectious Disease and Signaling Research, Nation...

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ژورنال

عنوان ژورنال: Journal of Computational Biology

سال: 2005

ISSN: 1066-5277,1557-8666

DOI: 10.1089/cmb.2005.12.1029